Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations
Year: 2025
Type: article
Abstract: This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states.
Source: Scientific Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Tecnologias com base em Eletrónica Orgânica e Bioelectrónica e as suas aplicações nas ciências da saúde, monitorização do meio ambiente e da qualidade de alimentos., G1483381719, G1516346500, G1578237752, G1781884919, Centro de Investigação Marinha e Ambiental, G3383689680, G3429697412, G3850789590, G3872268596, G3891694003, G4138542676, G4680224365, Centro de Ciências do Mar do Algarve, G5389921940, Centro de Ciências do Mar do Algarve, G59476441, G6316164294, G6547834732, G6912052472, G6997658380, G702508671, G7063316358, G8428786692
OpenAlex ID: W4413138954