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Photoredox Mediated Synthesis of Substituted Imidazoles from Terminal Alkynes

Year: 2025

Type: article

Abstract: A visible light photoredox-induced approach for the synthesis of substituted imidazoles via alkynes, glycine methyl ester, and thiophenol is presented. The reaction is facilitated by the photoinduced activation of alkynes, coupled with thiol, which generates a vinylic radical. This radical subsequently undergoes a nucleophilic addition to glycine methyl ester, serving as a nitrogen source, thereby leading to the formation of imidazoles through the concurrent creation of two carbon-nitrogen bonds.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202501097

Authors: Jaswant Kumar, Sourav Kumar, Syed Mohib Ali, Masood Ahmad Rizvi, Bhahwal Ali Shah

Institutions: Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, University of Kashmir

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Arthritis National Research Foundation

OpenAlex ID: W4413139088

FWCI: 1.162

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Cited by: 4

Related to: 10