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Mediastinal Nodal Evaluation May Be Safely Omitted in Select Patients With Ground Glass-Dominant Lung Adenocarcinoma

Year: 2025

Type: editorial

Abstract: In the article that accompanies this editorial, Dr. Zhang and colleagues report on a randomized controlled trial in which patients with cT1N0 invasive adenocarcinoma with a consolidation-to-tumor ratio (CTR) ≤ 0.5 were randomized to undergo systematic mediastinal nodal sampling vs. no mediastinal nodal evaluation at the time of segmentectomy or lobectomy; disease-free survival, safety outcomes, and rates of nodal metastases were assessed. No patient in either group was found to have nodal metastases, reinforcing the indolent nature of ground glass predominant adenocarcinoma and suggesting that for well-selected patients, mediastinal nodal sampling may be omitted without adverse oncologic outcomes.

Source: Journal of Clinical Oncology

DOI: 10.1200/jco-25-01578

Authors: Alexis P. Chidi, David R. Jones

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute