Accelerated Atherosclerosis in Early-Stage Breast Cancer Following Chemotherapy
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: No present guidelines exist regarding the inclusion of atherogenic cancer or chemotherapy into atherosclerotic cardiovascular disease (ASCVD) screening or imaging screening guidelines. Individual physician preference often determines screening, and this is typically symptom guided. CASE SUMMARY: A 30-year-old woman with early-stage breast cancer received atherogenic chemotherapy, with no prior atherogenic risk factors. She presented with angina and dyspnea on exertion 3 years after her last round of chemotherapy. An ischemic work-up was performed, and the patient was found to have premature critical stenosis in her proximal left anterior descending artery. DISCUSSION: Because more patients are living with cancer and survivors of atherogenic chemotherapy emerge, it is becoming more critical to improve ASCVD screening modalities. TAKE-HOME MESSAGE: Expert consensus for patients with early-stage cancer treated with atherogenic chemotherapy should derive either their unique ASCVD algorithm, be included into pre-existing algorithms, or have their own multimodal imaging pathway.
Source: JACC Case Reports
Institution: McLaren Regional Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $850
OpenAlex ID: W4413140129