Work

Incessant Electrical Storm in a Patient With Brugada Syndrome Provoked by Previously Unreported Syndrome-Inducing Medication

Year: 2025

Type: article

Abstract: BACKGROUND: Brugada syndrome is a disorder associated with an increased risk of syncope, ventricular fibrillation, and sudden cardiac death in a structurally normal heart. The condition is related to mutations in cardiac cell transmembrane channels, but many cases do not have identifiable genetic mutations. Arrhythmic events are usually induced by specific triggers including a number of medications. Ventricular storm in Brugada syndrome is rare but when it occurs it can be life threatening. CASE SUMMARY: We present a case of a patient receiving 5-fleurouracil home infusion monotherapy who developed prolonged ventricular storm and was found to have previously undiagnosed Brugada syndrome. The patient was successfully treated with isoproterenol, quinidine, and arrhythmogenic trigger reduction and made a full recovery. DISCUSSION: 5-flourouracil has never previously been reported as a possible inducer of Brugada syndrome. Additionally, this is the most prolonged case of electrical storm in a patient with Brugada syndrome reported to date.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.105014

Authors: Veniamin Melnychuk, Sharul Saxena, Kevin Ergle, Firas El Sabbagh

Institutions: HCA Florida Orange Park Hospital, First Coast Cardiovascular Institute

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850