Get started
Work

Proportional and functional anomalies of CD38+ NK Cells:A new mechanism for impaired anti-tumour immunity in multiple myeloma?

Year: 2025
Type: article
Abstract: The abnormal quantity and dysfunction of immune cells in patients with multiple myeloma impede anti-tumour immunity and prompt the occurrence and development of disease. It has been reported that CD38 + NK cells are involved in immune regulation. Peripheral blood (PB) samples were collected from healthy volunteers (HV) and newly diagnosed multiple myeloma (NDMM) patients. The proportions of CD38 + NK cells and CD38 + CD16 + NK cells were measured. Moreover, CD38 + NK cells separated from PB were co-cultured with RPMI-8226 assess their impact on myeloma cell apoptosis and proliferation. Similar co-culture experiments were also initiated with naive CD4 + T cells from HV to ascertain the influence of CD38 + NK cells on regulatory T cells (Tregs) differentiation. The percentages of CD38 + NK and CD38 + CD16 + NK cells in the PB of NDMM patients were markedly decrease than that in HV. The apoptosis rate of RPMI-8226 was slightly increased following co-culture with CD38 + NK cells from NDMM samples, as opposed to those from HV samples. CD38 + NK cells from NDMM or HV had similar inhibitory effect on MM cell proliferation. Furthermore, CD38 + NK cells from NDMM fostered CD4 + T cell differentiation to Tregs more than those from HV. In MM, the proportion and function of CD38 + NK cells undergo changes, which may be related to the formation of the immunosuppressive microenvironment. • The proportions of CD38 + NK cells and CD38 + CD16 + NK cells declined in peripheral blood of NDMM patients. • CD38 + NK cells of NDMM promoted apoptosis and inhibited proliferation of MM cells. • CD38 + NK cells of NDMM promoted Tregs differentiation.
DOI: 10.1016/j.imbio.2025.153107
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,840
OpenAlex ID: W4413143594
FWCI: 0.589
Cites: 35
Cited by: 2
Related to: 10