Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and IQ : Findings From the EU ‐ GEI Multicentre Case–Control Study

Year: 2025

Type: article

Abstract: ABSTRACT Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first‐episode psychosis (FEP) and community controls. Methods Patients with FEP ( N = 602) and controls ( N = 853) from the EU‐GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction ( p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls ( p = 0.826). Conclusions The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.

Source: Early Intervention in Psychiatry

DOI: 10.1111/eip.70079

Institutions: Libera Università Maria SS. Assunta, King's College London, University of Palermo, Centre Hospitalier Universitaire Vaudois, Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, GGZ Noord-Holland-Noord, Università degli Studi di Enna Kore, University of Verona, University of Bologna, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria de Santiago, Instituto de Salud Carlos III, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Universitat de València, Hospital Virgen de la Luz, Universidade de São Paulo, University of Cambridge, National Health Service, Université Clermont Auvergne, Cambridgeshire and Peterborough NHS Foundation Trust, Inserm, Fondation FondaMental, Assistance Publique – Hôpitaux de Paris, Amsterdam University Medical Centers, Maastricht University Medical Centre, GGZ Rivierduinen, Utrecht University, University Medical Center Utrecht

Language: English

Topic: Child Abuse and Trauma

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,060

Funders: Carigest, Fundación Alicia Koplowitz, Universidad de Sevilla, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Instituto de Investigación Sanitaria de Santiago de Compostela, Universidad Internacional de La Rioja, Fondation FondaMental, Amsterdam University Medical Centers, Leverhulme Trust, King's College London, European Commission, Institut National de la Santé et de la Recherche Médicale, Fundação de Amparo à Pesquisa do Estado de São Paulo, Universiteit van Amsterdam, Universiteit Utrecht, Universiteit Maastricht, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Rivierduinen, Universitat de València, Università degli Studi di Palermo, Universidade de São Paulo, Universitat de Barcelona, Università di Bologna, Universidad de Oviedo, Centre Hospitalier Universitaire Vaudois, Centro de Investigación Biomédica en Red de Salud Mental, Università degli Studi di Verona, INCLIVA Instituto de Investigación Sanitaria, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Medical Research Council, Economic and Social Research Council, Instituto de Salud Carlos III, European Regional Development Fund, National Institute of Mental Health

Awards: G1332902014, The role of the endocannabinoid system and cannabis use in the expression of psychosis, G1422126554, G1520406698, G1886919625, G1973349908, G2157603779, G2170376007, G2562062227, G2572068296, G2914487839, G2962925092, G3210393749, G3389329809, G3403558654, G3426433705, G3572747598, G3764841371, Interacciones genes-ambiente en las trayectorias de salud mental de los jóvenes, Estudio integral de variación genética y molecular de una cohorte española de trastornos del espectro autista y diseño de algoritmos de diagnóstico genético y de biotipos terapéuticos. Cohorte ESTEA., G4920756221, G4937468798, G5543596241, G5565498353, Psychiatric Ratings using Intermediate Stratified Markers 2, G5965028591, G6081615879, Pathways to psychosis among cannabis users, Autism Innovative Medicine Studies – 2 – Trials, G6972650492, Integrating psychological models with biological pathways in psychosis, G7070498705, G7094983079, G7131769662, Centre for Society and Mental Health, Enfoque integral y translacional para el diagnóstico genético de TEA: Caracterización clínica, G7636808386, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions, G842865865, G8494123976, G8563726104, G8726972595, G8824911526, G8950770007

OpenAlex ID: W4413147943