Work

Cyclodextrins in action: Modulating candida albicans biofilm formation and morphology

Year: 2025

Type: article

Abstract: • Randomly methylated cyclodextrins exhibited high bioactivity against C. albicans. • Synergetic effect of farnesol and CD in reducing biofilm formation was demonstrated. • Random methylated cyclodextrins increased the antifungal activity of farnesol. • Potential applicability of RAMEA and RAMEG as anticandidal compound was explored. The primary objective of this research was to explore the bioactive potential of cyclodextrins in attenuating biofilm formation in C. albicans . The concentration-dependent effects of both native cyclodextrins and specific derivatives were studied at concentrations ranging from 0.1 to 12.5 mM, to determine the mechanisms by which the extent of biofilm formation can be reduced. Besides, the efficiency of various combinations of cyclodextrins and farnesol, as an antifungal substance, were examined. The present study revealed both stimulatory and inhibitory effects of cyclodextrins on biofilm formation, depending on the structure and concentration. The bioactive potential of randomly methylated α- and γ-CD showed significant antifungal properties, as evidenced by a reduction in the biofilm formation. In addition, randomly methylated cyclodextrins were found to significantly enhance the antifungal activity of farnesol against C. albicans . Consequently, their synergistic effect may provide an excellent opportunity to produce a lower dose but more effective anticandidal formulation.

Source: Biotechnology Reports

DOI: 10.1016/j.btre.2025.e00912

Authors: Rita Márton, Hanna Hermann, Virág Tünde Kiss, Éva Fenyvesi, Lajos Szente, Mónika Molnár

Institutions: Budapest University of Technology and Economics, CycloLab (Hungary)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,480