Work

Structure–activity relationship study of substituted 1,2,3-thiadiazoles as novel nitrification inhibitors for agriculture

Year: 2025

Type: article

Abstract: O). Unfortunately, and for reasons not well understood, the current commercial inhibitors have shown inconsistencies in their performance across various agroecosystems, underscoring the need for the development of new nitrification inhibitor compounds to increase agriculture's environmental sustainability. In this work, we have performed structure-activity relationship (SAR) studies to explore the potential of 12 mono- and disubstituted 1,2,3-thiadiazoles as nitrification inhibitors through laboratory soil incubations. 1,2,3-Thiadiazoles substituted with one or two methyl groups as well as those with a fused cyclopentyl ring showed the most promising inhibitory activities, which can outperform the commercial nitrification inhibitor 3,4-dimethylpyrazole (DMP). Larger alkyl substituents as well as substituents with polar functional groups showed poorer or no inhibitory activity. These data align with our previous findings for substituted 1,2,3-triazoles that short, non-polar alkyl substituents on the heteroaromatic framework are beneficial for nitrification inhibitory properties.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00930h

Authors: Parvinder Kaur Sidhu, Yue Ming, Uta Wille

Institution: The University of Melbourne

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Australian Research Council

Awards: ARC Research Hub for Innovative Nitrogen Fertilisers and Inhibitors, New fertiliser technologies for sustained food security