Work

The Impact of Physicochemical Descriptors on the Biological Activity of 5-Fluorouracil Analogs

Year: 2025

Type: article

Abstract: 5-FU remains a key anticancer drug, especially for colon, breast, and other cancers. This study developed a QSAR model to predict the anticancer activity of seven 5-FU analogs. Physicochemical properties, calculated using ChemSW and GAMESS software, showed a strong correlation with experimental IC50 values (R²), validating the model's predictive capability.

Source: Journal of Kufa for Chemical Sciences

DOI: 10.36329/jkcm/2025/v4.i2.19415

Author: Falah Shareef Abed Suhail

Institution: Islamic University of Najaf

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413154257

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