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Use of Granulocyte-Colony Stimulating Factor for Beta-Lactam Induced Neutropenia in Children With Bacterial Meningitis

Year: 2025

Type: article

Abstract: Drug induced neutropenia is an uncommon but potentially serious side effect in children receiving prolonged β-lactam antibiotic therapy. Management of β-lactam induced neutropenia in children remains challenging and often requires antibiotic therapy interruption or modification. There are limited data in pediatric patients about use of granulocyte-colony stimulating factor (G-CSF) for the treatment of drug induced neutropenia. We report the use of G-CSF for β-lactam induced neutropenia in four pediatric patients between the ages of 3 months and 18 years with bacterial meningitis in this case series.

Source: The Journal of Pediatric Pharmacology and Therapeutics

DOI: 10.5863/jppt-24-00073

Authors: Cheng Yu Yen, Sheldon L. Kaplan, Debra L. Palazzi, Grant Stimes

Institutions: Texas Children's Hospital, Baylor College of Medicine

Language: English

Topic: Neutropenia and Cancer Infections

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413154464

FWCI:

Cites: 11

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Related to: 10