Work

Lumbrokinase-loaded GelMA hydrogels with inflammatory regulatory capacity promote vascularized bone regeneration in critical-sized cranial defects

Year: 2025

Type: article

Abstract: evaluations confirmed the hydrogel's efficient LK loading and sustained release profile. The combined effects of enhanced osteogenesis, angiogenesis, and immunomodulation significantly improved critical-sized bone defect regeneration, demonstrating substantial potential of the LK-loaded GelMA hydrogel for clinical translation in the reconstruction of critical-sized bone defects.

Source: RSC Advances

DOI: 10.1039/d5ra04178c

Authors: Yao-Wen Zhang, Sheng-Tao Zhao, Yi-Fei Ma, Yi-Hui Pan, Xiang-Zhen Yan

Institution: Tongji University

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042