Work

When panniculitis becomes lymphoma: Timely diagnosis and treatment of a subcutaneous panniculitis-like T-cell lymphoma hiding in plain sight

Year: 2025

Type: article

Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cytotoxic cutaneous T-cell lymphoma that is typically localized to the subcutaneous adipose tissue and presents with associated constitutional symptoms. This is a unique dermatopathological neoplasm, characterized by peri-eccrine atypical lymphocytic infiltrates extending into subcutaneous fat, expressing cytotoxic T-cell phenotype along with cytotoxic granule-associated proteins, in addition to a high Ki-67 proliferation index. This case report illustrates the characteristic clinical features, diagnostic challenges, histopathological findings, and successful therapeutic management of SPTCL in a young adult female.

Source: Journal of Hematology and Allied Sciences

DOI: 10.25259/jhas_28_2025

Authors: G. Vinayak, Jayasree M. Govindan, Surij Salih, Varun Rajan

Institutions: Lakeshore Hospital, Medical Trust Hospital

Language: English

Topic: Cutaneous lymphoproliferative disorders research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413177148