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Case report: Synchronous bladder and retroperitoneal paragangliomas: an extremely rare entity

Year: 2025

Type: article

Abstract: Paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. The synchronous occurrence of bladder and retroperitoneal PGLs is extremely rare. This case highlights the radiological features of dual-site PGLs and their potential for misdiagnosis as bladder cancer with retroperitoneal lymph node metastasis. A 59-year-old female patient was admitted with a 2-week history of abdominal distention. Imaging showed a highly vascularized 1.3 cm × 1.2 cm nodule on the right wall of the bladder and a retroperitoneal mass measuring 1.8 cm × 3.7 cm adjacent to the left side of the abdominal aorta. Postoperative pathological examination confirmed dual-site PGLs. The multifocal appearance and hypervascular characteristics of these tumors may lead to misdiagnosis as bladder cancer with metastasis. Recognizing the clinical, imaging (such as CT and MRI findings), and pathological features is crucial for avoiding misdiagnosis and formulating an appropriate treatment plan.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1593934

Authors: Weitao Huang, Yiming Liu, Miaoping Zhou

Institutions: Wenzhou Medical University, Quzhou City People's Hospital

Language: English

Topic: Adrenal and Paraganglionic Tumors

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801