Work

Altered brain network centrality in patients with cervical spondylotic myelopathy: insights from resting-state fMRI

Year: 2025

Type: article

Abstract: Objective To investigate the characteristics of brain network centrality in patients with cervical spondylotic myelopathy (CSM) by using degree centrality (DC) based on resting-state functional magnetic resonance imaging. Methods We recruited 20 patients with CSM, along with 20 healthy controls (HC) who were matched in terms of age, gender, and educational background. The DC method was utilized to evaluate the changed spontaneous brain activities. The relationships between the DC values of different brain regions and the clinical features were analyzed by means of Pearson correlation analysis. Results Compared with HC, CSM group showed decreased DC values in the left medial frontal gyrus, middle temporal gyrus and angular gyrus, and increased DC values were found in the left middle occipital gyrus, right supplementary motor area (p < 0.05). There was no significant correlation between DC values of abnormal region and clinical function score of CSM patients (p > 0.05). Conclusion CSM patients have abnormal DC distribution in the whole-brain functional networks, which might be related to cortical reorganization after chronic spinal cord injury.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1614935

Authors: Kaifu Wu, Hui Zheng, Yan Jiang, Shutong Zhang, Xiang Wang

Institutions: Central Hospital of Wuhan, Huazhong University of Science and Technology

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801