Work

Effects of Moringa oleifera Leaf Peptide on Hypoglycemic Activity In Vitro and Postprandial Glycemic Response in Beagle Dogs

Year: 2025

Type: article

Abstract: Moringa oleifera leaf (MOL) and their extracts have been demonstrated to possess hypoglycemic effects in a variety of species, but they are still unknown in dogs. This study examined the effects of Moringa oleifera leaf peptide (MOLP) on α-amylase and α-glucosidase activities. Furthermore, we assessed the impact of MOLP on the estimated glycemic index (eGI) of snacks in vitro and the postprandial glycemic response in dogs. The findings indicated that MOLP exhibited significant inhibitory activities against α-amylase (IC50 = 2.29 ± 0.10 mg/mL) and α-glucosidase (IC50 = 2.80 ± 0.04 mg/mL). Moreover, the MOLP-containing snacks exhibited a lower rate of starch hydrolysis during in vitro digestion, leading to a notable reduction in the eGI when compared to white bread (WB) and control snacks. Incorporating MOLP into snacks causes smoother alterations in postprandial blood glucose, significantly reducing glucose peak, time to peak, and glycemic index (GI). Our findings indicate that MOLP exhibits hypoglycemic potential, offering a scientific foundation for the future development of functional foods aimed at managing diabetes in dogs.

Source: Animals

DOI: 10.3390/ani15162361

Authors: Wencan Wang, Ling Xu, Yong Cao, Guo Liu, Yan Zhang, Xin Mao

Institutions: South China Agricultural University, Zhongkai University of Agriculture and Engineering, Sichuan Water Conservancy Vocational College

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896