Work

Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration

Year: 2025

Type: article

Abstract: literature suggests that, within canonical reward-related brain regions such as the nucleus accumbens (NAc), multiple reward-seeking behaviors may be represented by distinct neural populations. This comparison is often made between drug and natural rewards, however there is evidence for a similar distinction between psychostimulants and opioids. Here, we review the evidence for distinct neurobehavioral characteristics of psychostimulant versus opioid self-administration and consider the utility of two experimental approaches-miniscope calcium imaging and deep learning-assisted behavior analysis-in further exploring this topic.

Source: Addiction Neuroscience

DOI: 10.1016/j.addicn.2025.100224

Authors: Matthew C. Broomer, Caroline E. Clark, Jan Shanelle J. Iringan, Michael W. Wang, Nicholas J. Beacher, Da-Ting Lin