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Recurrent Spontaneous Hypothermia in an Elderly Woman: A Rare Neurological Case of Late-Onset Shapiro Syndrome

Year: 2025

Type: article

Abstract: An 81-year-old woman with a known diagnosis of Shapiro syndrome presented with recurrent hypothermia and delirium. This diagnosis had previously been made following multiple hospital admissions, extensive investigations, and imaging that showed corpus callosum agenesis. Shapiro syndrome is a rare neurological disorder characterised by episodic hypothermia and autonomic dysfunction. Management in this case was guided by an individualised care plan and supportive measures. This report highlights the diagnostic complexity of Shapiro syndrome and the importance of clinical awareness in older adults with unexplained hypothermia.

Source: Cureus

DOI: 10.7759/cureus.89920

Authors: Aye Thinzar Moe, Sujata Lama, Thi Han, Kyaw Soe Tun

Institutions: King's College Hospital NHS Foundation Trust, King's College Hospital

Language: English

Topic: Thermal Regulation in Medicine

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413187537