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Anti-TIF1-Gamma Autoantibodies-Positive Juvenile Dermatomyositis Associated With Interstitial Lung Disease: A Case Report

Year: 2025

Type: article

Abstract: Juvenile dermatomyositis (JDM) is a rare autoimmune disease in children, characterized by muscle inflammation and skin manifestations. This case report describes a nine-year-old boy with JDM associated with anti-TIF1-γ antibodies and interstitial lung disease (ILD). The patient presented with progressive muscle weakness and characteristic skin lesions. Imaging confirmed ILD, and treatment with methylprednisolone pulses and rituximab resulted in significant improvement. This case emphasizes the need for pulmonary monitoring in JDM patients, regardless of antibody profile, and highlights the importance of personalized treatment approaches.

Source: Cureus

DOI: 10.7759/cureus.89905

Authors: Ricardo Cid-Puente, Isaac A Carreon-Meza, David A Herrera-VanOostdam

Institutions: Universidad Autónoma de Zacatecas "Francisco García Salinas", Hospital Central Dr. Ignacio Morones Prieto

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413189741