Work

Encountering the unicorn – abscopal effect after fractionated stereotactic radiosurgery for brain metastasis in renal cell carcinoma: a case report and review of the literature

Year: 2025

Type: article

Abstract: Clear cell renal cell carcinoma (ccRCC) is a malignancy with a diverse clinical presentation, often characterised by its resistance to conventional therapies. We present the case of a 53-year-old Indian male diagnosed with ccRCC, pT3aN0M1exhibiting lymphovascular invasion and non-contiguous tumour deposits in the left adrenal gland. Following an initial course of Pazopanib and subsequent Everolimus, the disease progressed. Notably, just 3 months after receiving fractionated stereotactic radiosurgery (FSR) for a cerebellar metastasis, spontaneous regression was observed at a distant skeletal site. This case highlights the significance of considering FSR as a therapeutic option for selected patients with ccRCC, as well as the potential role of an abscopal effect to impact the course of this aggressive malignancy.

Source: ecancermedicalscience

DOI: 10.3332/ecancer.2025.1964

Authors: Nishana Abbas, Durgapoorna Menon

Institutions: Tata Memorial Hospital, Aster Medcity

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,226