Work

GGTLC1 Is a Prognostic Biomarker in Renal Clear Cell Carcinoma

Year: 2025

Type: article

Abstract: Kidney renal clear cell carcinoma (KIRC), the most common type of renal cell carcinoma, is an immunobiologically and metabolically distinct tumor. Its clinical management is closely related to the tumor microenvironment (TME). Identifying its potential markers is important for improving prognosis. Therefore, in this study, we successfully constructed a prognostic model of glutathione metabolism–related molecules and screened for GGTLC1 prognostic molecules, while immunohistochemical analysis of the online database HPA and hospital patient specimens showed that GGTLC1 was highly expressed in paracancerous tissues. Taken together, the results of this study suggest that GGTLC1 is a potential prognostic biomarker associated with KIRC. Trial Registration: Chinese Clinical Trial Registry identifier: LSKY: 2022‐112‐01

Source: International Journal of Genomics

DOI: 10.1155/ijog/7524935

Authors: Shi Li, Lijun Shi, Xiaofeng Tao, Guanghai Yu, Jianbo Wang

Institutions: Dalian University of Technology, First Affiliated Hospital of Dalian Medical University, Dalian University, Affiliated Zhongshan Hospital of Dalian University

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,380