Work

The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects

Year: 2025

Type: conference-paper

Abstract: Excess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and immune system activation. One of the components of the immune and inflammatory system is CC-chemokine ligand 2 (CCL2), which is secreted by adipose cells. This study aimed to analyze the role of CCL2 by comparing the serum CCL2 levels between obese and non-obese subjects at Warmadewa University. Employing a cross-sectional design, sixty participants were selected through consecutive sampling and assessed for body weight, height, and serum CCL2 levels using the ELISA method. Data were analysed using the independent t-test. The p-value <0.05 was significant. This study indicated that serum CCL2 levels were significantly lower in obese individuals, measuring 111.57 ± 33.51 pg/mL, compared to 133.44 ± 44.91 pg/mL in individuals with normal weight. This difference was statistically significant, with a p-value of 0.0370. CCL2 levels in normal subjects were found to be higher than in obese subjects, suggesting a possible alteration in chemokine regulation associated with obesity. Further studies are needed to explore the underlying mechanisms.

Source: BIO Web of Conferences

DOI: 10.1051/bioconf/202518401007

Authors: Asri Lestarini, Anak Agung Sri Agung Aryastuti, Ni Putu Diah Witari, Ni Wayan Erly Sintya Dewi

Institution: Warmadewa University

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413201796