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Synthesis of axially chiral 5,5′-substituted 2,2′-bipyridine ligands and their application in palladium-catalyzed asymmetric oxidative [2 + 2] annulation

Year: 2025

Type: article

Abstract: A series of axially chiral 5,5'-substituted 2,2'-bipyridine ligands featuring tunable properties have been synthesized. These ligands have been successfully applied to palladium-catalyzed asymmetric oxidative [2 + 2] annulation of arylboronic acids and alkenes, providing a diverse range of chiral benzocyclobutenes in excellent enantioselectivities with a broad substrate scope.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob01000d

Authors: Kai Xue, Jian Chen, Yu-Qing Bai, Bo Wu, Yong-Gui Zhou