Polypharmacy and Potential Drug Interactions in Hospitalised Patients with Type 2 Diabetes Mellitus
Year: 2025
Type: article
Study design: Observational Study
Abstract: Diabetes mellitus is a prevalent chronic disease often accompanied by comorbidities that require multiple medications, increasing the risk of potential drug interactions. This study analysed the association between polypharmacy and potential drug interactions in hospitalised patients with type 2 diabetes mellitus at Kramat Jati Regional General Hospital. A retrospective cross-sectional study was conducted using medical records of 94 inpatients from October to December 2024. Potential drug interactions and their severity were assessed using Drugs.com, and statistical analysis was performed with the Chi-square test. Results showed that 93 patients (98.8%) experienced potential drug interactions, predominantly of moderate severity (82.5%). The most frequent interaction was between metformin and ranitidine. A significant association was observed between polypharmacy and potential drug interactions (p = 0.002). These findings highlight the importance of early detection and management of drug interactions in type 2 diabetes mellitus inpatients, with clinical pharmacists playing a crucial role in optimising therapy safety.
Authors: Aries Meryta, Rahmat Widiyanto, Muhammad Fathan Nugrah Utama, Septia Wafa Khairiyah
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413208702