Work

Immune evasion strategies of Seneca Valley virus: mechanisms of host innate immune suppression

Year: 2025

Type: article

Abstract: Seneca Valley virus (SVV), an emerging picornavirus, poses a significant threat to the global swine industry. Innate immunity acts as the initial defense mechanism of host cells against viral infection. Upon infection, viruses can be detected by the cellular host's pattern recognition receptors (PRRs), which trigger the activation of signaling cascades and the strong production of type I interferon (IFN-I) to limit viral replication. SVV employs diverse strategies to evade innate immunity, primarily through 3C protease, which targets host antiviral proteins to antagonize IFN-I signaling. Additionally, SVV hijacks autophagy, apoptosis, and pyroptosis to facilitate its own replication. In this review, we summarize recent research on the underlying mechanisms employed by SVV to manipulate host innate immune response and programmed cell death pathways. This review will provide insights for the design of SVV vaccines and contribute to the prevention and control of SVV infection.

Source: Agriculture Communications

DOI: 10.1016/j.agrcom.2025.100100

Authors: Shijie Xie, Jingyu Yan, Bo Jiang, Jue Liu, Jiangwei Song

Institutions: Beijing Academy of Agriculture and Forestry Sciences, Washington University in St. Louis, Yangzhou University

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,600