Work

MicroRNAs as emerging biomarkers for chronic wound monitoring: Analytical methods for the point-of-care detection

Year: 2025

Type: article

Abstract: Chronic wounds represent a significant clinical challenge due to their prolonged healing time and susceptibility to infection and inflammation. Recent advances in molecular diagnostics have identified microRNAs as promising biomarkers for real-time monitoring of wound status, given their regulatory roles in the three phases of the healing process: inflammation, proliferation, and tissue remodeling. This review explores the potential of microRNAs as diagnostic tools for chronic wound management, with special focus on analytical strategies suitable for point-of-care (POC) detection like paper-based lateral flow assays or electrochemical techniques. We critically assess the advantages and limitations of current technologies regarding sensitivity, specificity, integration, and usability in decentralized healthcare settings. • Comprehensive overview of the potential of microRNAs as diagnostic tools for chronic wound management. • Focus on analytical strategies suitable for POC detection: lateral flow assays and electrochemical techniques. • Advantages and limitations regarding sensitivity, specificity, integration, etc. are critically assessed. • Principles of the different strategies are discussed, and some examples of relevant approaches are highlighted. • Prospects and challenges are finally given.

Source: Journal of Pharmaceutical and Biomedical Analysis

DOI: 10.1016/j.jpba.2025.117110

Authors: Diego Alvarez-Rafael, Alfredo de la Escosura-Muñiz

Institution: Universidad de Oviedo

Language: English

Topic: Biosensors and Analytical Detection

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,680