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Coronary flow and resistance patterns indexed by subtended myocardial mass in coronary microvascular dysfunction

Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: ; structural CMD). However, coronary flow is intimately linked to myocardial mass, potentially confounding the interpretation of flow and resistance measurements. AIMS: We investigated the relationship between subtended myocardial mass, microvascular resistance, and coronary flow to determine whether the disturbed resistance and flow patterns seen in CMD persisted after indexing by subtended myocardial mass. METHODS: ) ≥475 Wood units (WU) defined structural CMD (versus functional CMD). Flow and resistance measurements were analysed both in absolute terms and after indexing by subtended mass. RESULTS: to controls. CONCLUSIONS: , supporting the notion of hyperaemic flow restriction at the tissue level that is independent of subtended mass. However, patients with functional CMD have similar subtended myocardial mass to controls and exhibit no flow restriction during hyperaemia.
DOI: 10.4244/eij-d-25-00229
Authors: Thabo Mahendiran, Nikolaos Stalikas, Emanuele Gallinoro, Danielle Keulards, Koshiro Sakai, Frederic Bouisset, Michele Mattia Viscusi, Sara Corradetti, Jeroen Sonck, Marcel van ’t Veer, Adriaan Wilgenhof, Nico H.J. Pijls, Carlos Collet, Bernard De Bruyne
Institutions: Centre Hospitalier Universitaire Vaudois, Onze Lieve Vrouwziekenhuis Hospital, IRCCS Ospedale Galeazzi - Sant'Ambrogio, Catharina Ziekenhuis, SHOWA Medical University, St. Francis Hospital, Eindhoven University of Technology, Sapienza University of Rome
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W4413220707
FWCI: 1.592
Cites: 35
Cited by: 3
Related to: 10