Changes in non-culprit coronary lesions with PCSK9 inhibitors: the randomised, placebo-controlled FITTER trial
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: BACKGROUND: Prolonged lipid-lowering therapy has demonstrated its ability to induce plaque regression and improve the plaque morphology of mild atherosclerotic lesions. AIMS: This trial aimed to assess the short-term effect of evolocumab in addition to high-intensity statin therapy (HIST) on relevant non-culprit coronary artery lesions using fractional flow reserve (FFR) measurements and multimodality intracoronary imaging. METHODS: ). The secondary endpoints were the differences in the change in IVUS-derived atheroma volume parameters. RESULTS: was -27.8 (95% CI: -72.2 to 16.6) for evolocumab-treated patients versus -35.6 (95% CI: -82.5 to 11.4) for placebo-treated patients (adjusted mean difference: 7.8, 95% CI: -40.9 to 56.4; p=0.8). No between-group differences in any IVUS-derived parameter were found. CONCLUSIONS: . (ClinicalTrials.gov: NCT04141579).
Source: EuroIntervention
Authors: Frans B. Mensink, Jonathan Los, Mohamed M. Reda Morsy, Rohit M. Oemrawsingh, Clemens von Birgelen, Alexander J.J. Ijsselmuiden, Martijn Meuwissen, Jin M. Cheng, Diederik F. van Wijk, Pieter C. Smits, Valeria Paradies, Dirk J. van Wijk, Himanshu Rai, Tim J.F. ten Cate, Cyril Camaro, Peter Damman, Lokien X. van Nunen, Aukelien C. Dimitriu-Leen, Marleen H. van Wely, Aysun Cetinyurek-Yavuz, Robert A. Byrne, Niels van Royen, Robert-Jan M. van Geuns
Institutions: Radboud University Medical Center, Assiut University, Albert Schweitzer Ziekenhuis, Medisch Spectrum Twente, Maastricht University Medical Centre, Maastricht University, Amphia Ziekenhuis, Noordwest Ziekenhuisgroep, Medisch Centrum Haaglanden, Stichting Haaglanden Medisch Centrum, Maasstad Ziekenhuis, Royal College of Surgeons in Ireland, Mater Misericordiae University Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Amgen, Royal College of Surgeons in Ireland, InfraRedx, Radboud Universiteit, Universiteit Maastricht, Maastricht Universitair Medisch Centrum, Radboud Universitair Medisch Centrum, Assiut University, Faculty of Medicine, Assiut University, Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont
OpenAlex ID: W4413220771