Work

Oxyresveratrol derived from Artocarpus lakoocha extract represents a potential natural agent for treating acne and skin inflammation

Year: 2025

Type: article

Abstract: Acne and skin infections are associated with bacterial infections, inflammation, and oxidative stress.Oxyresveratrol, a major bioactive component of Artocarpus lakoocha, exhibits antibacterial activity against various bacteria.However, its activity against Cutibacterium acnes, a key acne-causing bacterium, remains underexplored.Therefore, in the present study, we aimed to evaluate the therapeutic potential of oxyresveratrol extracted from A. lakoocha Roxb., focusing on its antibacterial, antioxidant, cytotoxic, and anti-inflammatory properties.We evaluated three extracts obtained from the heartwood of A. lakoocha: crude AR, AR06, and AR061.Oxyresveratrol demonstrated strong antibacterial activity with inhibition zones of 16.37-31.90mm and minimum inhibitory concentrations ranging from 0.01-0.12mg/ml, exhibiting bactericidal effects within 24 hours.The antioxidant activity, measured based on halfmaximal inhibitory concentration (IC 50 ), was 30 µg/ml.Moreover, cytotoxicity assays using human skin fibroblasts revealed moderate cytotoxicity with an IC 50 of 6.08 ± 1.28 mg/ml.Notably, oxyresveratrol significantly inhibited prostaglandin E2 production at non-cytotoxic concentrations (0.07-0.31 mg/ml) with inhibition rates ranging from 6.64%-16.69%.These findings establish oxyresveratrol as a promising natural agent for use in skin care formulations, offering a safer alternative to conventional treatments for acne and inflammation.

Source: Journal of Applied Pharmaceutical Science

DOI: 10.7324/japs.2025.v15.i11.5