Work

Brain Atrophy Can Predict the Severity and Prognosis of Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Year: 2025

Type: article

Abstract: Background and Purpose Compare clinical and lab characteristics of anti-N-methyl-Daspartate receptor (anti-NMDAR) encephalitis cases with and without brain atrophy.Methods Assess cerebral atrophy using median temporal lobe atrophy (MTA) and global cortical atrophy (GCA) scores in 82 anti-NMDAR encephalitis cases.Results GCA (+) cases had higher proportions of status epilepticus (p<0.001),memory problems (p=0.031),sepsis (p<0.001), and mechanical ventilation need (p=0.001)than GCA (-) cases.MTA (+) cases had higher memory problems (p<0.001)and sepsis (p=0.002)than MTA (-) cases.GCA (+) and MTA (+) groups had higher max modified Rankin Scale (mRS) (p<0.001,p=0.002) and 1-year mRS (p<0.001,p=0.004) scores than GCA (-) and MTA (-) groups.GCA (+) group had a longer hospital stay and a larger proportion of cases with limited treatment response (both p<0.001) than the GCA (-) group.GCA (p=0.005) was found to be a significant predictive factor for the mRS score 1 year after onset in multiple linear regression analysis.Conclusions MTA and GCA may be associated with severity and prognosis in anti-NMDAR encephalitis.

Source: Journal of Clinical Neurology

DOI: 10.3988/jcn.2024.0524

Authors: Yinyao Lin, Haiyan Li, Yanling Li, Yuge Wang, Yongqiang Dai, Bingjun Zhang

Institution: Third Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Sun Yat-sen University, Guangdong Medical Research Foundation, Basic and Applied Basic Research Foundation of Guangdong Province