Sepsis-Induced Purpura Fulminans in a Patient with Advanced Chronic Liver Disease: A Call for Timely Intervention
Year: 2025
Type: article
Study design: Case Report
Abstract: Purpura fulminans is a severe thrombotic condition and hematologic emergency marked by disseminated intravascular coagulation and endovascular thrombosis. Timely recognition and treatment are crucial to reduce its high morbidity and mortality. This condition is linked to significant acquired deficiencies in protein C and dysfunction in the protein C-thrombomodulin pathway. Management involves treating the underlying infection, aggressive anticoagulation, and substantial transfusion support to correct deficiencies in natural anticoagulant proteins. We present a case of acute infectious Purpura fulminans with disseminated intravascular coagulation due to pneumonia in a middle-aged male with advanced chronic liver disease.
Source: Sri Lanka Journal of Medicine
Authors: B. D. C. H. Keerthisinghe, S. T. De Silva
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413227834