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The expression pattern and role of circulating CXCR5+γδ T cells in children with newly diagnosed immune thrombocytopenia

Year: 2025

Type: article

Abstract: Introduction Immune thrombocytopenia (ITP) is the most common bleeding disorder in children. Tfh cells play a crucial role in the pathogenesis of ITP by promoting the production of anti-platelet autoantibodies. Recent studies have shown that CXCR5+γδ T cells not only possess “Tfh-like” cell functions but also can induce Tfh cell differentiation. However, it remains unknown whether CXCR5+γδ T cells are involved in the pathogenesis of ITP. This study aims to investigate the role of CXCR5+γδ T cells in children with newly diagnosed ITP (nITP). Methods A total of 96 children with nITP and 48 healthy children were enrolled in this study. FCM was used to compare the frequencies of circulating CXCR5+γδ T cells and circulating Tfh cells, as well as the levels of ICOS and CD40l on circulating CXCR5+γδ T cells in both groups. The correlation between circulating CXCR5+γδ T cells and platelets as well as circulating Tfh cells were further analyzed. Results Compared with healthy controls, the frequency of circulating CXCR5+γδ T cells was higher in children with nITP, and it was negatively correlated with platelet count. The levels of ICOS and CD40l on circulating CXCR5+γδ T cells in children with nITP were also higher. Children with nITP had a higher frequency of circulating Tfh cells, which was positively correlated with circulating CXCR5+γδ T cells. Conclusions The excessive activation and proliferation of CXCR5+γδ T cells may contribute to the pathogenesis of nITP in children. Therefore, it can be used as a target for the immunotherapy of pediatric ITP.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1646877

Authors: Jian-Yong Wang, Yi Xin, Xiao-Li Wang, Lin-Lin Li, Ai-Min Li, Xiao-Lu Zhang

Institutions: Qingdao University, Yuhuangding Hospital

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801