Work

AMY109, an interleukin-8 antibody, as a potential target for endometriosis treatment: a commentary

Year: 2025

Type: article

Abstract: Interleukin-8 (IL-8) is a proinflammatory cytokine released during infections, inflammation, and tissue damage. Acting as a potent chemoattractant, IL-8 attracts inflammatory cells such as neutrophils and macrophages to sites of injury. Furthermore, IL-8 is often produced and released by a plethora of cells including neutrophils, macrophages, lymphocytes, endothelial, and epithelial cells. In addition to being proinflammatory, IL-8 is also a proangiogenic factor that promotes migration and growth of endothelial cells through matrix metalloproteinase production and the inhibition of endothelial cell apoptosis, which facilitates wound and tissue repair.

Source: F&S Reports

DOI: 10.1016/j.xfre.2025.08.003

Authors: Taylor R. Wilson, Katherine A. Burns

Institution: University of Cincinnati

Language: English

Topic: Endometriosis Research and Treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000