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Potentially Inappropriate Medication Use in Patients With Parkinson's Disease: Analysis of Korean National Health Insurance Claims Data

Year: 2025

Type: article

Abstract: Background and Purpose Polypharmacy is common in Parkinson's disease (PD).This includes appropriate medications for PD-related symptoms and comorbid conditions, but also potentially inappropriate medications (PIMs).We aimed to determine the prescribing trends of PIMs based on the 2019 Beers Criteria in Korean patients with PD.Methods This retrospective observational study analyzed PD patients aged 40 years or older whose PIM prescribing patterns from 2014 to 2019 were included in the HIRA (Korean Health Insurance Review and Assessment Service) nationwide claims database in South Korea.The prevalence and usage were analyzed for both overall PIMs and PIMs that can exacerbate PD symptoms (PIM PD s).Additionally, the most frequently prescribed PIMs and PIM PD s were investigated. ResultsPIMs were used at least once in 38.3% of 257,142 patients with PD.The mean number of PIM items used per patient was 2.61.The PIM usage ratio, corresponding to the proportion of the total amount of PIMs to all medications per patient, was 19.7%.The proportion of patients taking PIMs among all PD patients decreased significantly up to 2018 but then increased in 2019, while the PIM usage ratio increased steadily up to 2018 and then decreased in 2019.Excluding the representative PD medications, the most frequently prescribed PIM was amitriptyline.PIM PD s were also commonly used, including levosulpiride and haloperidol. ConclusionsThe prevalence and usage of PIMs were high in Korean PD patients during 2014-2019, and the utilization of PIM PD s persisted throughout this period.These findings can be used to develop evidence-based guidelines for robust polypharmacy management strategies to ensure the safety of medications used by PD patients.

Source: Journal of Clinical Neurology

DOI: 10.3988/jcn.2025.0122

Authors: Seon-Min Lee, Jieun Shin, Do-Young Kwon, Yu Jin Jung

Institutions: Konyang University, Konyang University Hospital, Korea University Ansan Hospital, Kyung Hee University, Kyung Hee University Hospital at Gangdong

Language: English

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Konyang University, Korea Health Industry Development Institute