Work

A Rare Case of Subcutaneous Scalp Mass As the Initial Presentation of Melanoma of Unknown Primary

Year: 2025

Type: article

Abstract: Melanoma is a form of skin cancer responsible for the majority of skin cancer-related deaths. Melanoma of unknown primary origin that presents as a periosteal scalp mass without overlying skin changes is rare and diagnostically challenging. Clinically, melanoma often presents as a skin lesion that is asymmetric, has irregular borders, exhibits multiple colors, is larger in size, and shows recent changes in appearance. The patient in this case is an 89-year-old male who initially presented with a subcutaneous cyst on the posterior scalp. Pathological examination of the excised mass ultimately confirmed malignant melanoma of unknown primary origin. A positron emission tomography scan performed after surgery revealed abnormal uptake in bilateral pulmonary nodules and multiple bilateral hilar lymph nodes. This case report highlights the clinical presentation, diagnostic challenges, and possible etiologies of melanoma with an unknown primary site that has metastasized to an unusual location.

Source: Cureus

DOI: 10.7759/cureus.89752

Authors: Megan Miller, Greeshma Ragu, Patrick D Plummer, Hui Un Kim, Matthew Passeggiata, Shawn Clark

Institutions: Ross University School of Medicine, Northeast Ohio Medical University, American University of Antigua, Western Reserve Hospital

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413231258