Work

Malignant high-grade unclassifiable spindle cell sarcoma in the hand: A diagnostic and therapeutic challenge

Year: 2025

Type: article

Abstract: INTRODUCTION: Spindle cell sarcoma is a rare malignancy characterized by spindle-shaped cells, often mimicking other tumors and posing diagnostic challenges due to its nonspecific clinical features. This case highlights the importance of a multidisciplinary approach and demonstrates the feasibility of complete tumor resection with functional preservation, even in large and complex tumors. CASE PRESENTATION: A 51-year-old woman with no significant medical history presented with a large, exophytic mass on her left hand, causing notable functional impairment in daily activities. Physical examination revealed a rubbery mass, measuring 15 × 8 cm. Imaging studies, including radiography, computed tomography, and magnetic resonance imaging, were performed. Given the impact of grasp functionality on daily life, surgical resection was scheduled. The excised tissue was subsequently submitted for histopathological evaluation. RESULTS: Imaging demonstrated a vascularized mass without bone involvement. Initial biopsy suggested multicentric cellular dermatofibroma. However, histopathological examination of the excised specimen revealed findings consistent with high-grade spindle cell sarcoma. Immunohistochemistry showed positivity for CD99 and CD56, with negative markers for S-100, factor XIII, TLE-1, CD34, SOX10, H3K27ME, SS18 and actin. At the 10-month follow-up, she remained recurrence-free with preserved hand function. CONCLUSIONS: A meticulous surgical approach is vital for the management of the balance of complete tumor excision and preservation of hand function. A thorough histopathological examination is necessary for diagnosis. Collaboration across disciplines is key to improving treatment outcomes.

Source: JPRAS Open

DOI: 10.1016/j.jpra.2025.08.001

Authors: Victor Hugo Garzón-Ortega, Kenzo Alejandro Fukumoto-Inukai, Carlos A. Morales-Morales, Yusef Jiménez-Murat

Institution: Hospital General Dr. Manuel Gea Gonzalez

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,920