Work

Cobalt(I)‐Catalyzed E‐Selective Hydroalkynylation of Terminal Alkynes or Internal Alkynes with Silyl‐Substituted Terminal Alkynes

Year: 2025

Type: article

Abstract: A stereoselective cross‐dimerization between silyl‐substituted donor alkynes and aryl‐ or alkyl‐substituted terminal acceptor alkynes using an in situ generated Co(I)‐phosphine catalyst is reported. The reaction optimization for both classes of acceptor alkynes is conducted via Design of Experiments and showed high E‐selectivities using different reaction conditions. Moreover, activated internal alkynes are successfully applied as acceptor alkynes in the cross‐hydroalkynylation, leading to highly substituted 1,3‐enynes in good regioselectivities and good to excellent yields.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500682

Authors: Sebastian M. Weber, Gerhard Hilt

Institution: Carl von Ossietzky Universität Oldenburg

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: Deutsche Forschungsgemeinschaft