Trichosporon inkin meningitis in a pediatric patient diagnosed via metagenomic sequencing
Year: 2025
Type: article
Study design: Case Report
Abstract: ABSTRACT Background Trichosporon has emerged as an important cause of invasive fungal infections in immunocompromised patients. There are limited data on invasive Trichosporon infections in children. Case Summary We report a case of culture-negative Trichosporon inkin meningitis diagnosed via metagenomic next-generation sequencing of plasma and cerebrospinal fluid in an infant with retinoblastoma. In addition, we highlight the role of β-1,3-D-glucan in the diagnosis and therapeutic monitoring of trichosporonosis, and cross-reactivity of the cryptococcal antigen lateral flow assay with T. inkin . Conclusion This diagnosis, which was challenging to make in the absence of a positive culture, highlights the utility of metagenomic sequencing methods and fungal biomarkers in identifying infectious agents and ensuring timely diagnosis and management of patients with rare fungal infections of the central nervous system.
Source: ASM Case Reports
Authors: Kathryn Phillips, Karen P. Acker, Jin-Young Han, Christine M. Salvatore, Sallie R. Permar, Rebecca Marrero Rolón, Jamie Marino, Claire Dysart, David M. Berman, Charles Y. Chiu, Sarah E. Kidd, Lars F. Westblade, Melanie M. Dubois
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413247282