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Enhanced mRNA and pDNA delivery via PEGylated solid lipid nanoparticles with an optimally balanced ionizable/cationic lipid content

Year: 2025

Type: article

Abstract: This study presents the development of PEGylated solid lipid nanoparticles with an optimally balanced ionizable/cationic lipid content as an efficient and nontoxic delivery vehicle for diverse nucleic acid cargoes.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb00470e

Authors: Nipuni Maniyamgama, Ki Hyun Bae, Jialing Lee, James Hoi Po Hui, Yi Yan Yang

Institutions: Agency for Science, Technology and Research, National University of Singapore, Bioprocessing Technology Institute

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Agency for Science, Technology and Research, National Research Foundation Singapore

Award: G8428556902

OpenAlex ID: W4413248035

FWCI: 1.305

Cites: 49

Cited by: 5

Related to: 10