Work

Insights from TPPP3 and its family member proteins in neuronal diseases

Year: 2025

Type: article

Abstract: Tubulin polymerization-promoting protein family member 3 (TPPP3) is a neuronal-specific protein involved in cytoskeletal stability, axonal maintenance, and neuronal survival. Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson's disease and diabetic retinopathy. Unlike TPPP1, which is oligodendrocyte-specific, TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson's disease and glaucoma. Beyond the nervous system, TPPP3 has been linked to oncogenesis and tissue regeneration, suggesting potential roles in tumor suppression and wound healing. This review summarizes neuronal functions of TPPP3, therapeutic opportunities, and future research directions. Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.

Source: Neural Regeneration Research

DOI: 10.4103/nrr.nrr-d-25-00345

Authors: Mishal Rao, Kun-Che Chang

Institution: University of Pittsburgh

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500