Work

A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI

Year: 2025

Type: article

Abstract: Background Arterial pulsatility is one of the driving forces of glymphatic flow. Objectives To evaluate the feasibility of the pulsatility index (PI) of cortical arteries in the centrum semiovale (PI CSO ) as a novel non-invasive imaging biomarker for Alzheimer’s disease (AD) in the context of glymphatic function. Design Retrospective cross-sectional study. Setting Single tertiary academic center equipped with both 3.0 T MRI systems. Participants A total of 160 individuals were enrolled: 50 healthy volunteers, 46 cognitively normal controls, and 64 AD patients who underwent diffusion tensor imaging (DTI) and 2D phase-contrast MRI. Measurements Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index and PI CSO were assessed using 2D phase-contrast MRI. Correlations with age, DTI-ALPS index, and Mini-Mental State Examination (MMSE) scores were analyzed. Results PI CSO was significantly higher in the AD group than those in healthy volunteers (P<0.001) and cognitively normal aging (P=0.001) groups. PI CSO correlated positively with age (rho=0.613, P<0.001) and negatively with both the DTI-ALPS index (rho=-0.439, P<0.001) and MMSE scores (rho=-0.486, P<0.001) in total group. Conclusion PI CSO derived from 2D phase-contrast 3.0T MRI may serve as a novel imaging biomarker for Alzheimer’s disease in relation to glymphatic function.

Source: The Journal of Prevention of Alzheimer s Disease

DOI: 10.1016/j.tjpad.2025.100323