Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Motor impairment in Huntington's Disease (HD) includes chorea, bradykinesia, dystonia, and rigidity, causing Upper extremity (UE) impairments in daily activities. OBJECTIVES: Describe motor patterns and analyze execution times for buttoning a shirt in premanifest and manifest-HD versus controls; explore the relationship between clinical assessments and UE motor performance and assess interobserver reliability of the motor pattern coding system. METHODS: Cross-sectional observational study with 30 manifest-HD, 9 premanifest-HD, and 30 controls from Burgos University Hospital, Spain. Participants buttoned a five-button shirt and time spent and motor patterns were analyzed using Observer-XT-software. RESULTS: Significant differences were found in movement time and motor patterns between groups. Manifest-HD took nearly twice as long as controls to complete the task. Correlations were found with clinical assessments. Degree of interobserver agreement was excellent. CONCLUSION: Evaluating motor patterns helps in early detection of motor impairment, monitoring disease progression, and developing rehabilitation programs to maintain and improve UE function.
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4413258527