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Casual association between plasma CoQ10 levels and stroke: a mendelian randomization study

Year: 2025

Type: article

Abstract: Objective: The aim of this study is to investigate the causal relationship between plasma CoQ10 levels and stroke, as well as some cardiovascular diseases, using Mendelian randomization methods. Methods: Causal links were investigated through two-sample Mendelian randomization (MR) analysis. We identified genetic variants that showed significant associations with plasma CoQ10 levels. The inverse variance weighted (IVW) method was employed to estimate the effects. Additionally, sensitivity analysis was used to assess heterogeneity or pleiotropy. Results: Our MR analysis revealed that genetically predicted plasma CoQ10 levels was inversely associated with of any stroke (AS, OR = 0.803, 95% CI: 0.659–0.978, p =0.029), any ischemic stroke (AIS, OR = 0.792, 95% CI 0.651–0.964, p = 0.020) and small vessel stroke (SVS, OR = 0.512, 95% CI 0.294-0.892, p = 0.018). However, no associations were observed between genetically predicted plasma CoQ10 and large artery stroke (LAS), cardioembolic stroke (CES), intracranial hemorrhage (ICH), atrial fibrillation (AF), myocardial infarction (MI) or heart failure (HF). Conclusion: Our MR analysis implies a protective effect between higher plasma CoQ10 levels and AS, AIS or SVS. The results and the underlying pathways or mechanisms between plasma CoQ10 levels and stroke needs further investigation.

Source: Brain Conflux

DOI: 10.71321/f3e84374

Authors: Xuyang Liu, Yuyuan Gao, Xiaojing Yao, Xu Li, Yuming Xu

Institutions: Zhengzhou University, First Affiliated Hospital of Zhengzhou University, Third Affiliated Hospital of Zhengzhou University

Language: English

Topic: Coenzyme Q10 studies and effects

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Zhengzhou University, Chinese Academy of Medical Sciences