Work

High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

Year: 2025

Type: article

Abstract: DC populations, both Tpex expansion and therapeutic benefits are abrogated, confirming DC dependence. In addition, GSDME is validated as a gatekeeper of pyroptosis-driven antitumor immunity. This work provides a rationale for clinical trials combining ICI with high-dose AA.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2025.102291

Authors: Xiangyu Sun, Xiaoting Cai, Shangbiao Li, Ruozheng Pi, Zeqin Guo, Jiayu Jiang, Pinhao Wang, Jingrong Xiong, Zhuangzhuang Liu, Zixuan Rong, Zihang Yu, Xiaonan Zhang, Jiaqi Chen, Duanduan Han, Yanpei Zhang, Jiale Tan, Yan Lin, Zhuocheng Zou, Haochen Ai, Fangfang Kang, Xuejun Guo, Zhongyi Dong, Dehua Wu, Xue Bai

Institutions: Nanfang Hospital, Southern Medical University

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Guangzhou Science and Technology Program key projects, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1058239451, G1573192341, G2456705684, G7373519206

OpenAlex ID: W4413270257

FWCI: 4.319

Cites: 51

Cited by: 12

Related to: 10