Work

Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models

Year: 2025

Type: article

Abstract: , and supplying NO, via electrostatic interaction, redox reaction, complexing action, and biotransformation, respectively. Intravenous administered PEI-arg@MON@BA passively targets to the liver, significantly attenuates hepatic damage, decreases oxidative stress, reduces cfDNA-induced TLR9-MyD88-NF-ĸB signaling, and inhibits the inflammatory cascade in both IRI model and liver transplantation (LT) model in male rats. It also eliminates the danger signals in LT patient serums, and relieves the ischemic injury in human liver tissues, pathing important clinical translation prospects.

Source: Nature Communications

DOI: 10.1038/s41467-025-62968-4