Feeding-induced olfactory cortex suppression reduces satiation
Year: 2025
Type: article
Abstract: Binge feeding commonly leads to overeating. Experiencing flavor during food consumption contributes to satiation. Still, the interactions between flavor, binge feeding, and food intake remain unknown. Using miniscopes for in vivo calcium imaging in the anterior piriform cortex (aPC) in freely moving mice, we identified specific excitatory neuronal responses to different food flavors during slow feeding. Switching from slow feeding to binge feeding transformed these specific responses into an unspecific global suppression of neuronal activity. Consummatory aPC suppression scaled with food value. GABAergic neurons in the olfactory tubercle (OT) projected to the aPC and mirrored activity patterns in the aPC under different feeding conditions, consistent with transmitting a value signal. Closed-loop optogenetic manipulations demonstrated that suppressing the aPC during binge bouts reduces satiation by selectively prolonging feeding bouts. We propose that aPC suppression by the OT enhances food intake by reducing sensory satiation during binge feeding-associated states of high motivation.
Source: Neuron
Authors: Hung Lo, Walter Cañedo Riedel, Malinda L.S. Tantirigama, Anke Schoenherr, Laura Moreno Velasquez, Lukas Faiss, Amit Kumar, Aileen Hakus, Benjamin R. Rost, Matthew E. Larkum, Benjamin Judkewitz, Katharina Stumpenhorst, Marion Rivalan, York Winter, Eleonora Russo, Wolfgang Kelsch, Dietmar Schmitz, Friedrich W. Johenning
Institutions: Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Johannes Gutenberg University Mainz, Heidelberg University, University Medical Center of the Johannes Gutenberg University Mainz, Central Institute of Mental Health, University Medical Centre Mannheim, Medizinische Fakultät Mannheim, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, German Center for Neurodegenerative Diseases, Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut des Neurosciences Paris-Saclay, Scuola Superiore Sant'Anna
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $10,400
Awards: G122987265, G1478171108, G1680808902, G1717570230, G1923547659, G2218856400, G2707994935, FOR 3004: Pathophysiologie autoimmuner Enzephalitiden – SYNABS, SFB 1315: Mechanismen und Störungen der Gedächtniskonsolidierung: Von Synapsen zur Systemebene, Metabolische Statusabhängigkeit der Geschmacksrepräsentation im olfaktorischen Cortex bei hedonisch motivierter Überernährung, G388153354, GPRIN Proteine und ihr Einfluss auf die Funktion von Kainatrezeptoren, G434337789, SPP 1926: Next Generation Optogenetics: Tool Development and Application, EXC 2049: Comprehensive approaches to neurological and psychiatric disorders "NeuroCure", G6219790147, G6554162741, G7027221778, Der mediodorsale Thalamus als zentrale Schnittstelle des olfaktorischen Lernens, SFB 958: Einrüstung von Membranen: Molekulare Mechanismen und zelluläre Funktionen, G7951008679, Verbundprojekt: Die neurobiologischen Grundlagen Polyamin-induzierter Protektion gegen altersassoziierte Einschränkungen der Gedächtnisfunktionen (SMARTAGE), Teilprojekte der Charité - Universitätsmedizin Berlin, G8580271377
OpenAlex ID: W4413270533