Work

Dupilumab Initiation for Surgically Refractory Chronic Rhinosinusitis With Nasal Polyps Is Associated With Differential Expression of CLC and Activation of Eicosanoid Pathways

Year: 2025

Type: article

Abstract: KEY POINTS: An untargeted transcriptomic analysis provided exploratory insight into key genes and pathways that can be used to help identify patients at risk for surgically refractory chronic rhinosinusitis with nasal polyps (CRSwNP). The Charcot-Leyden crystal gene, periostin and osteopontin-associated pathways, eicosanoid synthesis pathway, and prostaglandin/leukotriene metabolism pathway, among others, are associated with dupilumab prescription for surgically refractory chronic rhinosinusitis and may support early stratification of disease severity in CRSwNP patients.

Source: International Forum of Allergy & Rhinology

DOI: 10.1002/alr.70019

Authors: Christina Dorismond, Rory J. Lubner, Daniel H. Lofgren, Chandler J. Rygalski, Ping Li, Katherine N. Cahill, Suman R. Das, Mason R. Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed I. Chowdhury

Institutions: Vanderbilt University, Vanderbilt University Medical Center, University of Mississippi Medical Center, University of Alabama at Birmingham

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,100

Funders: Burroughs Wellcome Fund, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G3468352185, G364208108, G3865978080, G559175514, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G9000035097, Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

OpenAlex ID: W4413272663

FWCI: 1.414

Cites: 11

Cited by: 2

Related to: 10