Work

Site-Selective Electrochemical Intramolecular C(sp 2 )–H Selenylation for Dibenzoselenophene Synthesis

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide We report a robust and eco-conscious electrosynthetic protocol for efficiently constructing structurally diverse and biologically relevant dibenzoselenophenes. This transformation proceeds via electrochemical intramolecular C–H activation of bis(biaryl) diselenides, employing LiClO 4 as a green electrolyte and tetrabutylammonium bromide as an additive, conducted in DMSO at 70 °C under a constant current of 10 mA using Pt/Pt electrodes. The newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free catalysis, short reaction times, high to excellent yields, broad substrate tolerance, scalability to gram-scale synthesis, operational simplicity, and environmental friendliness.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01600

Authors: Indrajit Karmakar, Yi-Xuan Jian, Wan-Lin Cheng, Rekha Bai, Yu-Hsuan Chen, Chin-Fa Lee

Institution: National Chung Hsing University

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Ministry of Education, India, National Chung-Hsing University, National Science and Technology Council, Science and Engineering Research Board