Work

Structural and functional properties of neodymium-doped hydroxyapatite nanoparticles for biomedical applications

Year: 2025

Type: article

Abstract: Neodymium (Nd³⁺) doped hydroxyapatite nanoparticles (Han: Nd³⁺ NPs) were synthesized and systematically characterized to evaluate their structural and functional properties for biomedical applications. X-ray diffraction (XRD) confirmed the crystalline phase retention post-doping, while x-ray photoelectron spectroscopy (XPS) revealed the successful incorporation of Nd³⁺ ions. The doping altered the optical and electronic properties, potentially enhancing bioactivity and imaging capabilities. Preliminary cytotoxicity assessments on MCF7 and 4T1 breast cancer cell lines indicated dose-dependent effects, with IC50 values of 36.13 µg/mL and 64.38 µg/mL, respectively. The study concludes that Han: Nd³⁺ NPs offer promise as multifunctional platforms for cytotoxic response and structural stability, with potential for future application in imaging and targeted breast cancer therapy.

Source: Biotechnology Reports

DOI: 10.1016/j.btre.2025.e00916

Authors: K.Sai Manogna, K. Kusuma, G.Rajasekhara Reddy, B.Deva Prasad Raju, N.John Sushma

Institutions: Sri Padmavati Mahila Visvavidyalayam, Yeungnam University, Sri Venkateswara University

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,480