Work

Minimalist mRNAs: A fast track to cancer vaccines

Year: 2025

Type: article

Abstract: The manuscript by Esprit et al. analyzes the relevance of different elements of in vitro-transcribed (IVT) mRNAs in order to simplify their use as cancer vaccines.1 The authors concluded that some elements generally considered stabilizing —such as 5′ and 3′ untranslated regions (UTRs) and the poly(A) tail— could be dispensable for mRNAs used to express small antigens by antigen-presenting cells (APCs). In addition, they developed a simple method for generating synthetic DNA templates (SDTs), accelerating the production of small mRNAs and allowing rapid high-throughput screening of cancer neoepitopes.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102669

Authors: Laura Salaberry, Ángela Covo-Vergara, Uxue Beloki, Noelia Silva-Pilipich, Cristian Smerdou

Institutions: Navarre Institute of Health Research, Centro de Investigación Médica Aplicada

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900